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Overview
ROHan is a Bayesian framework to estimate local rates of heterozygosity, infer runs of homozygosity (ROH) and compute global rates of heterozygosity outside of ROHs. ROHan can work on modern and ancient samples with signs of ancient DNA damage.
ROHan can work for sample with depth-of-coverage 4-5X or above for modern samples and 7-8X for damaged ancient samples. It makes the following assumptions:
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